| Product name: |
CD10 Rabbit pAb |
| Reactivity: |
Human, Rat, Mouse |
| Alternative Names: |
CALLA, Enkephalinase,MME,NEP, Neutral endopeptidase antibody |
| Source: |
Rabbit |
| Dilutions: |
IHC 1:200-500 |
| Immunogen: |
Recombinant Protein |
| Storage: |
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid?repeated?freeze-thaw?cycles. |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1mg/mL |
| Observed Band: |
85kDa |
| GeneID: |
4311 |
| Human Swiss-Prot No: |
P08473 |
| Cellular localization: |
Cell membrane |
| Background: |
CD10 is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably the amyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease. Synthesized as a membrane-bound protein, the neprilysin ectodomain is released into the extracellular domain after it has been transported from the Golgi apparatus to the cell surface. In neurons, neprilysin is regulated by the protein nicastrin, a component of the gamma secretase complex that performs a necessary step in processing amyloid precursor protein to amyloid beta. |
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